Endothelin (ET) is a 21-amino acid peptide that is an important component of disease progression in pulmonary arterial hypertension (PAH), a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction. ET has both acute and chronic effects that are mediated by two receptors—ETA and ETB.
At EndothelinScience.com, you will find:
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a review of ET and its roles in normal physiology and pathology
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a discussion of how ET contributes to the pathogenesis of PAH
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an introduction to a therapeutic intervention—endothelin receptor antagonism—that is addressing the problem of excess ET in pathology
A comprehensive bibliography and other education resources are also available to aid you as you research this exciting and evolving field of medical science.
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