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Right Ventricular Strain and Dysfunction |
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Increased vascular resistance associated with endothelin (ET)-mediated arteriopathy in pulmonary arterial hypertenson (PAH) forces the right ventricle of the heart to work harder. Over time, this leads to right ventricular hypertrophy, reduced contractility, and reduced blood flow to the right ventricular myocardium. Acute or chronic ischemia may result.1 The strain and dysfunction experienced by the right ventricle in the late stages of PAH commonly lead to right heart failure.1 |
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Pulmonary Arterial Hypertension |
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Clinical Definition2 |
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Mean pulmonary arterial pressure >25 mm Hg |
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Pulmonary capillary wedge pressure
≤15 mm Hg |
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Pulmonary vascular resistance >3 Wood units |
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REFERENCES |
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1. |
Rich S, McLaughlin VV. Pulmonary hypertension. In: Libby P, Bonow RO, Mann DL, Zipes DE. Braunwald's Heart Disease. 2 vols. 8th ed. Philadelphia, PA: Saunders Elsevier; 2008:1883–1914. |
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McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension. J Am Coll Cardiol. 2009;53:1573–1619. |
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